A phosphatidylcholine hyaluronic acid chitin–nanofibrils complex for a fast skin remodeling and a rejuvenating look

BACKGROUND The reduction of mortality worldwide has led older individuals to seek intervention modalities to improve their appearance and reverse signs of aging. OBJECTIVE We formulated a medical device as innovative block-polymer nanoparticles based on phosphatidylcholine, hyaluronan, and chitin nanofibrils entrapping amino acids, vitamins, and melatonin. METHODS Viability and collagen synthesis were controlled on fibroblasts ex vivo culture while adenosine triphosphate production was evaluated on keratinocytes culture. Subjective and objective evaluations were performed in vivo on selected volunteer patients. RESULTS In accordance with our previous studies, both the in vitro and in vivo obtained results demonstrate the efficacy of the injected block-polymer nanoparticles in reducing skin wrinkling and ameliorating the signs of aging.